Lab News

2022


August 2022: The Walker lab has welcomed Ben Craine to the lab as an Undergraduate placement student. Ben will be with us for the next year conducting research before returning to the University of Exeter to complete his studies. Welcome Ben!

August 2022: The Walker lab is pleased to welcome Suraj Math to the lab as a research technician. Suraj recently completed a Bachelor of Science and Masters of Science from Pune University. Welcome Suraj!

July 2022: Dr. Stephanie Bouley presented at the NF Summit organized by the Children’s Tumor Foundation in Chicago, IL. She presented on the NF1 Sleep Study being conducted by the Walker and Saxena labs. You can learn more about the NF Summit here and about the NF1 Sleep Study here.

June 2022: The Walker lab has welcomed David Degidio as one of our new research technicians. David recently graduated from the University of Massachusetts Amherst with a Bachelor of Science. Welcome David!

June 2022: Dr. Torrey Mandigo presented at the annual Boston Area Drosophila (BAD) Meeting on June 16th on his post-doctoral research. His talk was entitled “Protein Glycosylation is a regulator sleep and circadian rhythms in Drosophila.” Learn more about BAD here.

June 2022: The Walker lab is pleased to welcome Annabelle Elsner for the summer. Annabelle is an undergraduate student from Eckerd College and is expected to complete her studies in 2024. Welcome Annabelle!

May 2022: The Walker Lab participated in the annual Steps2Cure NF Walk/Run in Wakefield, MA hosted by Neurofibromatosis Northeast under the team name Walker’s Walkers! Together, we were able to raise over $275 for NF research. Thank you for your support!

May 2022: Dr. Stephanie Joy Bouley recently presented at the 25th annual American Society for Gene and Cell Therapy (ASGCT) meeting in Washington D.C., which focuses on advancing knowledge, awareness, and education of gene and cell therapies.

May 2022: Research technician Nick LoRocco has accepted a M.D./Ph.D. position at The University of Chicago Pritzker School of Medicine Medical Scientist Training Program (MSTP). Congratulations Nick!

April 2022: Dr. James Walker received a grant from the Gilbert Family Foundation’s Gene Therapy Initiative grant. The Gilbert Family Foundation is a private foundation established by Jennifer and Dan Gilbert to accelerate a cure for neurofibromatosis type one (NF1) and build economic opportunity and equity in the city of Detroit. See: https://www.gilbertfamilyfoundation.org/research-project/optimization-of-base-and-prime-editing-strategies-for-nf1-therapeutics/

April 2022: Ph.D. Candidate Francisco Fernandez was recognized as part of this year’s Massachusetts General Hospital Graduate Student Appreciation Week.

March 2022: Stephanie Joy Bouley, Ph.D. has been selected to receive one of the slots in the Mass General Brigham (MGB) Precision and Genomic Medicine (P&GM) T32 Training Program. Congratulations Stephanie!

March 2022: Dr. Stephanie Joy Bouley gave a guest lecture as part of the “Emerging Biosciences – Straight from the Lab” Beacon Hill Seminar series. Her lecture focused on implementing novel gene editing strategies to treat Neurofibromatosis type 1.

2021


October 2021: The Walker Lab now has a twitter account! Be sure to follow us @WalkerLabMGH!

October 2021: The Walker lab was featured on the Children’s Tumor Foundation Blog along with our collaborator Dr. Ben Kleinstiver to discuss the impact that support form the NF1 Gene Therapy Initiative research program has had on our research. Read more here: https://bit.ly/3BdFcuB 

September 2021: Dr. Stephanie Joy Bouley was accepted to attend The Neurofibromatosis Young Investigators’ Forum (NFYIF), a highly competitive research and professional development forum that strives to encourage, promote, and empower Young Investigators to forge collegial connections and acquire the necessary skills and relationships to increase their research productivity and catalyze their career trajectory in neurofibromatosis. Learn more here: https://www.ceconcepts.com/NFYIF

September 2021: Graduate student Francisco Fernandez, along with several classmates, has published a paper in Nature Biotechnology on how community building should be integrated into the graduate classroom to foster the development of a professional identity and build connections between students and faculty to improve student wellness and support students from diverse backgrounds during the COVID-19 pandemic. Well done Francisco! You can read the paper here: https://www.nature.com/articles/s41587-021-01046-8

July 2021: We are happy to welcome Co-op students Austin Birmingham and Sophia Castellani to the Walker Lab. Both are undergraduate students from Northeastern University and are expected complete their studies in 2023. They will be working in the Walker lab for the next six months. Welcome Austin and Sophia!

June 2021: This month, both Dr. Jim Walker and Dr. Stephanie Joy Bouley presented at the annual NF Conference organized by the Children’s Tumor Foundation (CTF), which was held virtually this year. Dr. Bouley spoke on the laboratory’s efforts towards developing CRISPR-based gene therapies for Neurofibromatosis Type 1, while Dr. Walker focused on identifying novel drugs to treat NF1-associated tumors using genetic screens in Drosophila cells. The Walker lab is looking forward to attending next year’s meeting in person in Philadelphia, PA.

June 2021: The Walker lab is pleased to welcome Anya Thomas for the summer. Anya is an undergraduate student from Eckerd College and is expected to complete her studies in 2022. Welcome Anya!

May 2021: Graduate student Francisco Fernandez has passed his qualifying exam. Congratulations Francisco!

March 2021: Torrey Mandigo, Ph.D. was accepted as a Post-doctoral Fellow on the Harvard Medical School Research Training Program in Sleep, Circadian and Respiratory Neurobiology. Congratulations Torrey!

2020


November 2020: We are pleased to welcome Nicholas LoRocco to the Walker lab as a new research technician. Nick recently graduated from Northeastern University with his Bachelor of Science degree. Welcome Nick!

September 2020: The Walker lab is excited to welcome graduate student Francisco Fernandez to the lab. Francisco is pursuing a Ph.D. from the Biological and Biomedical Sciences Program at Harvard University. Welcome Francisco!

August 2020: We are pleased to welcome Research Fellow Torrey Mandigo, Ph.D to the Walker lab! Torrey recently graduated with his PhD in Molecular and Cellular Biology from Boston College. Welcome Torrey!

May 2020: Congratulations and farewell to Research Associate Brittany Leger, who is beginning her graduate school career at the University of California San Diego this fall. She will be greatly missed in the Walker lab. Good luck Brittany!

2019


October 2019: Dr. Stephanie Joy Bouley has received the Dorothy and Spiro Latsis Fellowship in Neurofibromatosis Research from Boston Children’s Hospital. With this two-year fellowship, Dr. Bouley will continue her work on identifying unique network signatures associated with NF1 loss in plexiform neurofibromas. Congratulations Stephanie!

September 2019: Dr. Jim Walker recently spoke at the annual NF Conference hosted by the Children’s Tumor Foundation in San Francisco, California. Dr. Walker’s talk, entitled “Modeling NF1 in Drosophila” kicked off the Animal Models session of the four-day conference and focused on the novel insights the fruit fly Drosophila has provided into NF1 biology.

May 2019: Dr. Jim Walker was one of two recipients to receive funding from the Children’s Tumor Foundation in the form of a NF1 Gene Therapy Initiative Award. Dr. Walker’s project focuses on investigating the feasibility of using genome editing (both CRISPR-based homology-directed repair and base editing) as a therapeutic approach to correct three pathogenic NF1 mutations in cultured human Schwann cells. We will capitalize on recently developed CRISPR/Cas9 and Cas12a variants, which increase the targeting range, activity, and fidelity (reducing off-targets) of gene-editing in collaboration with Dr. Ben Kleinstiver of the Center for Genomic Medicine at MGH.

March 2019: Research Associate Brittany Leger recently gave a Plenary Platform Presentation at the Genetics Society of America 60th Annual Drosophila Research Conference held in Dallas, Texas. This work is a result of a collaboration between the Walker and Saxena labs from the Center for Genomic Medicine at MGH, as well as with the Schreiber lab at the Broad Institute and focuses on the effects of ALG10 mutations and protein N-glycosylation on sleep and seizure phenotypes in a Drosophila model of ALG10 loss. Well done Brittany!

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